Methacrylic acid - methyl methacrylate copolymer (1:2), also known as methacrylic acid copolymer, Type B - NF, is an excipient used in pharmaceutical is a solid white powder with dissolution above pH of 7.0, and is used in enteric coatings for fast dissolution in the upper bowel, for granulation of drug substances in powder form for controlled-release, and for site-specific drug delivery. It is typically released in the upper bowel of the gastrointestinal tract.
S-100 is a commercially available methacrylic acid - methyl methacrylate copolymer with a ratio of 1:2. It is a white powder that is water-insoluble but dissolves above a pH of 7.0.
S-100 is widely used as a pharmaceutical excipient, particularly in enteric coatings, due to its ability to dissolve in the small intestine. It is also used for granulation and taste masking.
Copolymer Composition:
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S-100 is a copolymer, meaning it's a polymer made from two different monomers: methacrylic acid and methyl methacrylate. The ratio of these monomers is 1:2.
Pharmaceutical Applications:
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- Enteric Coatings: S-100's ability to dissolve in the small intestine makes it ideal for enteric coatings, which protect drugs from the stomach's acidic environment and ensure they dissolve in the upper intestine.
- Granulation: It can be used in the granulation of powder drugs for controlled-release formulations
- Taste Masking: S-100 can be used to mask the taste of unpleasant drugs.
- Other Uses:
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While primarily used in pharmaceuticals, S-100 may have other applications, such as in coatings and adhesives.
Physical Properties:
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S-100 is a white, free-flowing powder that is insoluble in water but dissolves in solutions above pH 7.0.